GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| UVM | cis | rs9902453 | 1 | rs56280226 | chr17:28429575 | EFCAB5 | chr17:28256874-28435469:+ | 0.4 | 4.97 | 6.82E-6 | Coffee consumption (cups per day) |
| UVM | cis | rs568617 | 1 | rs568617 | chr11:65653242 | SNX32 | chr11:65601410-65621170:+ | 0.63 | 5.51 | 9.72E-7 | Crohn's disease |
| UVM | cis | rs8078723 | 1 | rs56922390 | chr17:38157021 | GSDMA | chr17:38119226-38134019:+ | -0.87 | -7.55 | 4.73E-10 | Neutrophil count;White blood cell count;C-reactive protein and white blood cell count |
| UVM | cis | rs11190604 | 1 | rs57025426 | chr10:102205868 | SEC31B | chr10:102246403-102289636:- | -0.39 | -5.11 | 4.24E-6 | Palmitoleic acid (16:1n-7) plasma levels |
| UVM | cis | rs9902453 | 1 | rs57411618 | chr17:28273052 | EFCAB5 | chr17:28256874-28435469:+ | 0.39 | 4.9 | 8.89E-6 | Coffee consumption (cups per day) |
| UVM | cis | rs8141797 | 1 | rs5760229 | chr22:24560254 | SUSD2 | chr22:24577444-24585074:+ | 0.99 | 4.72 | 1.67E-5 | Amyotrophic lateral sclerosis |
| UVM | cis | rs8135828 | 1 | rs5763305 | chr22:29930195 | CABP7 | chr22:30116344-30127818:+ | -1.03 | -6.84 | 6.87E-9 | Lipid traits |
| UVM | cis | rs9902453 | 1 | rs59274738 | chr17:28437635 | EFCAB5 | chr17:28256874-28435469:+ | 0.4 | 4.97 | 6.82E-6 | Coffee consumption (cups per day) |
| UVM | cis | rs8078723 | 1 | rs59925331 | chr17:38169273 | GSDMA | chr17:38119226-38134019:+ | -0.87 | -7.55 | 4.73E-10 | Neutrophil count;White blood cell count;C-reactive protein and white blood cell count |
| UVM | cis | rs6003958 | 1 | rs6003958 | chr22:24264089 | LOC391322 | chr22:24373117-24374043:+ | -0.7 | -5.16 | 3.56E-6 | S-phenylmercapturic acid levels in smokers |
| UVM | cis | rs6051080 | 1 | rs6051080 | chr20:25975674 | FAM182B | chr20:25744102-25848786:- | 0.65 | 4.79 | 1.29E-5 | Colorectal or endometrial cancer |
| UVM | cis | rs9876781 | 1 | rs60512868 | chr3:48483445 | TREX1 | chr3:48501186-48509043:+ | -0.4 | -4.9 | 8.74E-6 | Longevity |
| UVM | cis | rs9902453 | 1 | rs60967688 | chr17:28437052 | EFCAB5 | chr17:28256874-28435469:+ | 0.4 | 4.97 | 6.82E-6 | Coffee consumption (cups per day) |
| UVM | cis | rs6151429 | 1 | rs6151429 | chr22:51063477 | ARSA | chr22:51063450-51066607:- | -0.88 | -5.18 | 3.26E-6 | Blood metabolite levels |
| UVM | cis | rs9902453 | 1 | rs62070270 | chr17:28263980 | EFCAB5 | chr17:28256874-28435469:+ | 0.39 | 4.9 | 8.89E-6 | Coffee consumption (cups per day) |